The world is neither flat nor two-dimensional, so why should cell culture be? Traditional cell culture systems grow cells on flat, coated, plastic dishes; however, these systems are not representative of what occurs in the human body. Since the early 2010s, techniques for growing organoids—a collection of organ-specific cell types that develops from stem cells or organ progenitors—have rapidly increased. Organoids are grown in 3D culture systems, in which cells thrive either in suspension or through a scaffold made with components from the extracellular matrix. Ranging in size from less than the width of a human hair to the width of a pencil eraser (50 µm–5 mm), organoids contain multiple organ-specific cell types that are spatially grouped together to replicate an organ and/or express an organ’s specific aspects or functions (e.g., contraction, neural activity, endocrine section, filtration, excretion).
So far, researchers have produced organoids that resemble the brain, kidney, lung, intestine, stomach, heart, and liver. This way of culturing tissues offers scientists a detailed view of how organs form and grow, provides new insights on human development and disease, improves drug discovery, and creates new approaches to personalized medicine.
In this webinar, our expert speakers will:
- Detail how to study induced pluripotent stem cells (iPSCs) and outline commonly used 3D organoid models and applications
- Provide an overview and update on current techniques to characterize 3D organoid models
- Discuss the challenges and advantages of 3D organoid models in drug discovery and precision medicine
- Answer your questions during the live broadcast.
This webinar will last for approximately 60 minutes.